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The integumentary system of an animal primarily refers to what?

  1. Muscle

  2. Skin

  3. Digestive system

  4. Nervous system

The correct answer is: Skin

The integumentary system is primarily associated with the skin, which serves as the body's outer protective layer. It plays a vital role in protecting underlying structures from environmental hazards, such as pathogens, chemicals, and physical injuries. Additionally, the skin is involved in thermoregulation, sensation, and the synthesis of important substances like vitamin D. The other options pertain to different body systems that do not align with the definition of the integumentary system. Muscle relates to the muscular system, which is responsible for movement; the digestive system pertains to food processing and nutrient absorption; and the nervous system is involved in transmitting signals and processing information throughout the body. Thus, the skin being the primary component of the integumentary system makes it the correct answer.